Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Fluoxetine toxicity in a preterm infant.

C G Mohan¹, J J Moore

¹Department of Pediatrics, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.

Journal of Perinatology : Official Journal of the California Perinatal Association

|November 15, 2000

Summary

Neonatal exposure to fluoxetine can cause motor automatism and skin issues in preterm infants. Symptoms resolved by 7 days, with normal neurodevelopment at 4 months.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Enhanced inhibition of Pseudomonas aeruginosa virulence factor production and biofilm development by sublethal concentrations of eugenol and phenyllactic acid.

Letters in applied microbiology·2022

Same author

α-Lipoic acid blocks the GMCSF induced protease/protease inhibitor spectrum associated with fetal membrane weakening in-vitro.

Placenta·2020

Same author

CD200 is a useful diagnostic marker for identifying atypical chronic lymphocytic leukemia by flow cytometry.

International journal of laboratory hematology·2018

Same author

In-vivo stretch of term human fetal membranes.

Placenta·2016

Same author

Decidual GM-CSF is a critical common intermediate necessary for thrombin and TNF induced in-vitro fetal membrane weakening.

Placenta·2014

Same author

Alleviation of transient global ischemia/reperfusion-induced brain injury in rats with 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose isolated from Mangifera indica.

European journal of pharmacology·2013

Area of Science:

Neonatal pharmacology
Developmental pediatrics
Clinical toxicology

Background:

Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine cross the placenta.
Neonatal adaptation to maternal medication exposure requires careful monitoring.
Understanding drug effects on preterm infants is crucial for clinical management.

Observation:

A preterm infant presented with significant motor automatism and dermatologic findings.
In utero exposure to fluoxetine was identified as the potential cause.
Elevated fluoxetine levels in the neonate were consistent with adult therapeutic ranges.

Findings:

Neurologic symptoms, including motor automatism, were observed in the neonate.
Skin manifestations were also noted in conjunction with neurologic signs.
Fluoxetine levels at 96 hours of age were 92 ng/ml, within the adult therapeutic range.

Implications:

This case highlights the potential for neonatal toxicity from maternal fluoxetine use.
Early identification and monitoring of neonatal symptoms are essential.
Resolution of symptoms and normal neurodevelopmental outcome suggest transient effects in this case.

Related Experiment Videos