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[Effectiveness of prestarium in the treatment of chronic cor pulmonale]
Aim:
To study efficiency and safety of application of perindopril (prestarium) in patients with chronic cor pulmonale (CCP).
Material And Methods:
The trial included 26 patients with chronic obstructive pulmonary disease complicated with CCP and cardiac failure of NYHA class II-III. The study group of 16 patients received perindopril 2-4 mg/day for 3 months. 10 controls received routine therapy. All the patients were examined before the treatment and 3 months after it using physical examination, echocardiography, Doppler echocardiography, 24-h Holter ECG monitoring, assessment of potassium and creatinine in the serum, quality of life.
Results:
The treatment decreased functional class of cardiac failure and mean pulmonary arterial pressure, lowered malignant arrhythmia frequency, improved quality of life and intracardiac hemodynamics, inhibited right ventricular remodelling.
Conclusion:
Perindopril is well tolerated and safe efficient medicine in patients with decompensated CCP.
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