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Ancistrolikokines A-C: new 5,8'-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko
G Bringmann1, C Günther, W Saeb
1Institut für Organische Chemie der Universität, Am Hubland, D-97074 Würzburg, Germany, Department of Chemistry, University of Peradeniya, Peradeniya, Sri Lanka. bringham@chemie.uni-wuerzburg.de
Journal of Natural Products
|November 15, 2000
Abstract:
Three new naphthylisoquinoline alkaloids, ancistrolikokines A-C (1-3), have been isolated and structurally assigned from Ancistrocladus likoko, as well as the known compound korupensamine A (4). Their 5,8'-coupling hints at a close biogenetic relationship of A. likoko to other Central African Ancistrocladus species. Compounds 1-4 showed good to moderate antimalarial activities when evaluated in vitro against the NF54 and K1 strains of Plasmodium falciparum.