Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Available pathways database (APD): an essential resource for combinatorial biology.

M C Pirrung1, C M Silva, J Jaeger

  • 1Department of Chemistry, Levine Science Research Center, Duke University, Durham, North Carolina 27708-0317, USA. pirrung@chem.duke.edu

Journal of Natural Products
|November 15, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physical and chemical properties of exopolysaccharide obtained from whey fermentation by <i>Lactiplantibacillus plantarum</i> DF60Mi.

Journal of food science and technology·2025
Same author

Seedling quality of Cordia trichotoma under different container volumes and fertilizers.

Brazilian journal of biology = Revista brasleira de biologia·2025
Same author

Green walls for greywater treatment: A comprehensive review of operational parameters and climate influence on treatment performance.

Water research·2024
Same author

Remote sensing in maize: effect of vegetal biostimulants application in three stages of development.

Brazilian journal of biology = Revista brasleira de biologia·2024
Same author

Surgeon experience in second-look transurethral resection of bladder cancer - a prospective study.

Actas urologicas espanolas·2023
Same author

Pathogens and microorganisms in the mangrove oyster Crassostrea gasar cultivated in an estuarine environment in Northeast Brazil.

Brazilian journal of biology = Revista brasleira de biologia·2023
Same journal

Polycyclic-Fused Cytochalasins with Anti-Liver Fibrosis Activity Produced by the Endophytic Fungus <i>Trichoderma harzianum</i>.

Journal of natural products·2026
Same journal

Oleraciamides A and B: Confirmation and Revision of Structures.

Journal of natural products·2026
Same journal

Synthesis and Stereochemical Revision of Violaceoid E, a Polyoxygenated Cyclohexanoid Natural Product Isolated from <i>Aspergillus violaceofuscus</i> Gasperini.

Journal of natural products·2026
Same journal

Cpumycins A-C, Aminated Benzoic Dimers from <i>Streptomyces</i> sp. CPU-W6, and Their Potential Cardioprotective Activities.

Journal of natural products·2026
Same journal

Editorial Introducing the Collection in Honor of Valerie J. Paul.

Journal of natural products·2026
Same journal

AI-Accelerated Structure Elucidation of Boavistamides A<b>-</b>C, Cyclic Depsipeptides from a Marine Filamentous Cyanobacterium Collected in Cabo Verde.

Journal of natural products·2026
See all related articles

The Available Pathways Database (APD) catalogs microbial natural products and their biosynthetic pathways. This resource aids combinatorial biology by enabling donor strain selection and revealing novel biosynthetic insights.

Area of Science:

  • Microbiology
  • Biochemistry
  • Bioinformatics

Background:

  • Microbial natural products are a rich source of novel compounds.
  • Combinatorial biology requires efficient access to diverse biological resources.
  • Understanding biosynthetic pathways is crucial for natural product discovery.

Purpose of the Study:

  • To create a comprehensive database of microbial natural products, producing strains, and biosynthetic pathways.
  • To facilitate donor strain selection for combinatorial biology experiments.
  • To explore novel aspects of biosynthetic routes through cataloging.

Main Methods:

  • Construction of a relational database, the Available Pathways Database (APD).
  • Inclusion of data on microbial natural products, producing strains, and biosynthetic pathways.

Related Experiment Videos

  • Data compilation for Version I of the APD.

    • Main Results:

    • The APD provides a resource for selecting donor strains for combinatorial biology.
    • The database serves a similar function for combinatorial biology as the Available Chemicals Directory (ACD) does for chemical library generation.
    • Initial compilation (Version I) revealed no 10-unit Type I polyketides.

    Conclusions:

    • The APD is a valuable resource for microbial natural product research and combinatorial biology.
    • The database facilitates the discovery of novel biosynthetic pathways.
    • Further development and data inclusion will enhance its utility for exploring microbial diversity.