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Andalasin A, a new stilbene dimer from Morus macroura
Y M Syah1, S A Achmad, E L Ghisalberti
1Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.
Fitoterapia
|November 15, 2000
Summary
Researchers isolated a new stilbene dimer, andalasin A, from Morus macroura wood. This compound exhibits weak antinematodal and moderate antifungal activities, suggesting potential applications in pest and disease control.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Medicinal Chemistry
Background:
- The Morus genus, particularly Morus macroura, is a rich source of bioactive stilbenoids and other phenolic compounds.
- Investigating the chemical constituents of medicinal plants can lead to the discovery of novel compounds with therapeutic potential.
Purpose of the Study:
- To isolate and characterize new chemical entities from the wood of Morus macroura.
- To evaluate the biological activities of the isolated compounds, specifically their antinematodal and antifungal properties.
Main Methods:
- Phytochemical investigation involving extraction and isolation techniques.
- Structure elucidation of the new compound using comprehensive spectroscopic data (e.g., NMR, MS).
- Bioassays to determine antinematodal and antifungal efficacy.
Main Results:
- Isolation and identification of a new stilbene dimer, andalasin A (1).
- Co-isolation of known compounds: oxyresveratrol and mulberroside C.
- Andalasin A demonstrated weak antinematodal activity and moderate antifungal properties.
Conclusions:
- Andalasin A is a novel stilbene dimer isolated from Morus macroura.
- The compound possesses promising biological activities that warrant further investigation for potential applications.