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Norfloxacin dihydrate.

A J Florence¹, A R Kennedy, N Shankland

¹Department of Pharmaceutical Sciences, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, Scotland. alastair.florence@strath.ac.uk

Acta Crystallographica. Section C, Crystal Structure Communications

|November 15, 2000

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Norfloxacin recrystallizes from acetonitrile as a dihydrate. The antibiotic molecule adopts a zwitterionic form in this crystalline structure, impacting its properties.

Area of Science:

Pharmaceutical Science
Crystallography
Medicinal Chemistry

Background:

Norfloxacin is a widely used fluoroquinolone antibiotic.
Understanding the crystalline structure of antibiotics is crucial for drug formulation and efficacy.

Purpose of the Study:

To characterize the crystalline form of norfloxacin obtained from acetonitrile.
To determine the molecular structure and hydration state of norfloxacin in this crystal.

Main Methods:

Recrystallization of norfloxacin from acetonitrile.
X-ray diffraction analysis to determine crystal structure.
Spectroscopic methods for molecular confirmation.

Main Results:

Norfloxacin successfully recrystallized from acetonitrile as a dihydrate.

Related Experiment Videos

The norfloxacin molecule was confirmed to exist in a zwitterionic form within the crystal lattice.

The chemical formula was identified as C(16)H(18)FN(3)O(3).2H(2)O.

Conclusions:

The zwitterionic dihydrate form of norfloxacin is stable when recrystallized from acetonitrile.
This structural information is vital for understanding norfloxacin's solid-state properties.
Potential implications for norfloxacin formulation and stability studies.