Related Experiment Video
Updated: Aug 21, 2026

Candida albicans Biofilm Chip (CaBChip) for High-throughput Antifungal Drug Screening
Published on: July 18, 2012
The effect of ethylenediamine-tetraacetic acid on Candida albicans
B H Sen1, B G Akdeniz, A A Denizci
1Department of Restorative Dentistry and Endodontology, Ege University, Izmir, Turkey. bbsen@superonline.com
Objectives:
The aim of this study was to evaluate the antifungal effect of ethylenediamine-tetraacetic acid (EDTA) on Candida albicans, comparing it with that of various disinfectants and common antifungal agents.
Study Design:
Two clinical oral isolates and 1 standard strain of C albicans were included in this study. Main contents of the test solutions were sodium hypochlorite, EDTA, chlorhexidine, hexetidine, benzalkonium chloride, povidone-iodine, nystatin, and ketoconazole. The agar diffusion method was used to determine the antifungal effects of the solutions. Zones of inhibition were recorded and the results were analyzed statistically by using a 2-way analysis of variance.
Results:
EDTA demonstrated the highest antifungal activity in comparison with routine antifungal drugs and all other solutions (P <.0001). Oral cavity isolate was more resistant to the test solutions (P <.0001).
Conclusion:
The selection of irrigating and disinfecting solution in root canals of patients with a particularly high incidence of oral candidiasis gains extreme importance. EDTA may be strongly recommended during endodontic therapy of these patients.
Related Concept Videos
Candidiasis
Antifungal Agents

