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Related Experiment Videos

Primary olfactory axons form ectopic glomeruli in mice lacking p75NTR.

K T Tisay1, P F Bartlett, B Key

  • 1Department of Anatomy and Cell Biology, University of Melbourne, Victoria 3052, Australia.

The Journal of Comparative Neurology
|November 15, 2000
PubMed
Summary

The low affinity nerve growth factor receptor (p75NTR) is not essential for initial olfactory nerve assembly but is crucial for postnatal olfactory bulb maturation. Its absence leads to aberrant axon growth and ectopic glomeruli formation.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • The low affinity nerve growth factor receptor, p75 neurotrophin receptor (p75NTR), is expressed by olfactory ensheathing cells.
  • This restricted expression suggests a role for p75NTR in olfactory nerve pathway development.

Purpose of the Study:

  • To investigate the role of p75NTR in the development of the primary olfactory system.
  • To elucidate the function of p75NTR in olfactory nerve assembly and olfactory bulb maturation.

Main Methods:

  • Comparative analysis of olfactory system development in p75NTR knockout mice and wild-type littermates.
  • Histochemical staining using Dolichos biflorus agglutinin to trace axon pathways.

Main Results:

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  • p75NTR is not essential for the initial formation of the olfactory nerve.
  • Absence of p75NTR results in excessive primary olfactory axon growth into the olfactory bulb.
  • Aberrant axon projections, bypassing the glomerular layer and forming ectopic glomerular-like tufts in abnormal tissue blebs, were observed.
  • Axon sorting and convergence onto glomeruli within these ectopic structures occurred.

Conclusions:

  • p75NTR plays a significant role in the postnatal maturation of the olfactory bulb's laminar cytoarchitecture.
  • p75NTR indirectly influences olfactory axon growth but does not appear to affect glomerular targeting.
  • The findings highlight p75NTR's importance in regulating the structural organization of the olfactory bulb after initial nerve formation.