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Chemical synthesis of a core 2 branched pentasaccharide containing a carboxylate group
J Xia1, J L Alderfer, K L Matta
1Molecular & Cellular Biophysics, Roswell Park Cancer Institute, Buffulo, NY 14263, USA.
Bioorganic & Medicinal Chemistry Letters
|November 15, 2000
Abstract:
Design and synthesis of a carboxylate-containing pentasaccahride 1 with the Galbeta(1-4) (Fucalpha1-3)GlcNAcbeta(1-6)[3-[1-carboxymethyl]-Galbeta+ ++(1-3)]GalNAcalpha-OMe sequence, which is obtained through regioselective coupling of the 6-OH of a novel acceptor 9 with Lewis(x) donor 10 catalyzed by NIS-TfOH are described.