Type 2 diabetes: to stimulate or not to stimulate the beta cell

Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation.

Chemical communications (Cambridge, England)·2014

Glucose regulation of β-cell stress in type 2 diabetes.

Diabetes, obesity & metabolism·2010

Neuronal nitric oxide synthase protects the pancreatic beta cell from glucolipotoxicity-induced endoplasmic reticulum stress and apoptosis.

Diabetologia·2010

Balancing needs and means: the dilemma of the beta-cell in the modern world.

Diabetes, obesity & metabolism·2009

Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets.

Diabetologia·2009

The role of mTOR in the adaptation and failure of beta-cells in type 2 diabetes.

Diabetes, obesity & metabolism·2008

Multi-omics dissection of MASLD reveals divergent pathways to systemic diseases and targets for prevention.

Metabolism: clinical and experimental·2026

Alpha-ketoglutarate ameliorates diabetes-associated skeletal muscle fibrosis by restoring TET2-dependent epigenetic remodeling in CD90 positive fibro-adipogenic progenitors.

Metabolism: clinical and experimental·2026

HSF1-UCHL1 transcriptional axis protects against MASLD via regulation of PPARα protein stability.

Metabolism: clinical and experimental·2026

Serine synergizes with lipopolysaccharide to induce macrophage pyroptosis through extracellular Hsp90α and early skin immune microenvironment disruption in diabetic foot.

Metabolism: clinical and experimental·2026

Apolipoprotein M: A liver-derived lipid-binding protein protects against heart failure with preserved ejection fraction by inhibiting TGF-β signaling.

Metabolism: clinical and experimental·2026

Glutamine synthetase deficiency triggers mitochondrial oxidative stress and a ribotoxic stress response during acute hepatic metabolic crisis.

Metabolism: clinical and experimental·2026

DECREASED ADIPOSITY RESULTING FROM REDUCED FOOD INTAKE LIKELY CONTRIBUTES TO THE AMELIORATION OF GENOTOXIC ALTERATIONS IN OMEGA-3-SUPPLEMENTED CAFETERIA DIET-FED MICE.

Mutagenesis·2026

Traditional Risk Factors Are Not Associated with the Rise of Early-Onset Colorectal Cancer: An All of Us Study.

Diseases of the colon and rectum·2026

Correction: Integrating multi-omics data reveals IL-8 positive cancer-associated fibroblasts as mediators of chemotherapy-induced tumor progression in breast cancer.

Frontiers in immunology·2026

Adaptive Surgical Decision-Making for Synchronous Metastatic Pancreatic Cancer and Early Breast Cancer with a BRCA1 Pathogenic Variant: A Case Report.

Surgical case reports·2026

Two Unrelated Families With Noncoding Duplications Upstream of MSX2 Refine the Critical Regulatory Region Likely Involved in Cranial Bone Development and a Cleidocranial Dysplasia-Like Phenotype.

Human mutation·2026

Diabetic ketoacidosis associated with pancreatic involvement in a patient with von Hippel-Lindau syndrome: a case report.

Frontiers in endocrinology·2026

Related Experiment Videos

Type 2 diabetes: to stimulate or not to stimulate the beta cell

Related Concept Videos

Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation.

Glucose regulation of β-cell stress in type 2 diabetes.

Neuronal nitric oxide synthase protects the pancreatic beta cell from glucolipotoxicity-induced endoplasmic reticulum stress and apoptosis.

Balancing needs and means: the dilemma of the beta-cell in the modern world.

Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets.

The role of mTOR in the adaptation and failure of beta-cells in type 2 diabetes.

Multi-omics dissection of MASLD reveals divergent pathways to systemic diseases and targets for prevention.

Alpha-ketoglutarate ameliorates diabetes-associated skeletal muscle fibrosis by restoring TET2-dependent epigenetic remodeling in CD90 positive fibro-adipogenic progenitors.

HSF1-UCHL1 transcriptional axis protects against MASLD via regulation of PPARα protein stability.

Serine synergizes with lipopolysaccharide to induce macrophage pyroptosis through extracellular Hsp90α and early skin immune microenvironment disruption in diabetic foot.

Apolipoprotein M: A liver-derived lipid-binding protein protects against heart failure with preserved ejection fraction by inhibiting TGF-β signaling.

Glutamine synthetase deficiency triggers mitochondrial oxidative stress and a ribotoxic stress response during acute hepatic metabolic crisis.

DECREASED ADIPOSITY RESULTING FROM REDUCED FOOD INTAKE LIKELY CONTRIBUTES TO THE AMELIORATION OF GENOTOXIC ALTERATIONS IN OMEGA-3-SUPPLEMENTED CAFETERIA DIET-FED MICE.

Traditional Risk Factors Are Not Associated with the Rise of Early-Onset Colorectal Cancer: An All of Us Study.

Correction: Integrating multi-omics data reveals IL-8 positive cancer-associated fibroblasts as mediators of chemotherapy-induced tumor progression in breast cancer.

Adaptive Surgical Decision-Making for Synchronous Metastatic Pancreatic Cancer and Early Breast Cancer with a BRCA1 Pathogenic Variant: A Case Report.

Two Unrelated Families With Noncoding Duplications Upstream of MSX2 Refine the Critical Regulatory Region Likely Involved in Cranial Bone Development and a Cleidocranial Dysplasia-Like Phenotype.

Diabetic ketoacidosis associated with pancreatic involvement in a patient with von Hippel-Lindau syndrome: a case report.

Related Experiment Videos

Type 2 diabetes: to stimulate or not to stimulate the beta cell

Related Concept Videos

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