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Generation and regeneration of a novel anti-CD8-resistant cytolytic T lymphocyte population

D S Dougall1, E S Lamousé-Smith, S A McCarthy

  • 1Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15213, USA.

Cellular Immunology
|November 18, 2000
PubMed

We recently reported that the in vivo development of a novel CD8(+), but anti-CD8 mAb-resistant, CTL population is complex and distinct from that of conventional anti-CD8 mAb-sensitive CD8(+) CTL. In this study, we explored the role of the thymus in the generation of anti-CD8-resistant pCTL and in their maintenance once they are generated. We also investigated the capacities of the adult periphery and thymus to support the regeneration of anti-CD8-resistant pCTL after peripheral lymphocyte and/or thymocyte depletion. These studies indicate that the thymus is necessary for the generation but not the maintenance of peripheral anti-CD8-resistant pCTL. These studies also indicate that the adult thymus can produce these pCTL and the adult periphery can support their regeneration, if a new wave of thymic maturation is experimentally induced. These results may have implications for immune reconstitution after treatment for cancer or HIV infection.

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