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Atypical hairy cell leukemia.

M L Wu1, H C Kwaan, C L Goolsby

  • 1Department of Pathology, Northwestern University Medical School, Chicago, IL, USA.

Archives of Pathology & Laboratory Medicine
|November 18, 2000
PubMed
Summary
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This study highlights a rare hairy cell leukemia case with unique CD10(+) immunophenotype, challenging existing classifications. Accurate diagnosis requires correlating clinical and pathological data for these B-cell neoplasms.

Area of Science:

  • Hematology
  • Oncology
  • Immunophenotyping

Background:

  • Mature B-cell neoplasms with cytoplasmic projections include splenic lymphoma with villous lymphocytes and hairy cell leukemia.
  • Hairy cell leukemia classification is debated, with classic, variant, and Japanese variants exhibiting distinct features.

Observation:

  • Classic hairy cell leukemia is typically CD11c(+), CD25(+), and CD103(+).
  • Variant and Japanese variants are usually CD11c(+), CD25(-), and occasionally CD103(+), but characteristically CD10(-).

Findings:

  • A unique hairy cell leukemia case presented with a CD10(+), CD25(+), and CD103(-) immunophenotype.
  • This case underscores the immunophenotypic variability within hairy cell leukemia variants.

Implications:

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  • Accurate diagnosis of hairy cell leukemia necessitates a comprehensive correlation of clinical and pathological data.
  • Understanding immunophenotypic variations is crucial for differentiating "hairy" B-cell neoplasms.