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Related Experiment Videos

Oxandrolone in trauma patients.

J M Gervasio1, R N Dickerson, J Swearingen

  • 1Department of Clinical Pharmacy, University of Tennessee-Memphis 38163, USA.

Pharmacotherapy
|November 18, 2000
PubMed
Summary

Oxandrolone administration did not improve nutritional status or clinical outcomes in multiple trauma patients. This study found no significant benefits in body composition or complication rates with oxandrolone treatment.

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Area of Science:

  • Trauma Care
  • Nutritional Support
  • Pharmacological Interventions

Background:

  • Multiple trauma patients often experience significant metabolic stress and catabolism.
  • Optimizing nutritional status is crucial for recovery and reducing complications.

Purpose of the Study:

  • To evaluate the efficacy of oxandrolone in improving nutritional and clinical outcomes in patients with multiple trauma.
  • To assess the impact of oxandrolone on nitrogen balance, body composition, and complication rates.

Main Methods:

  • A prospective, randomized, double-blind, placebo-controlled trial was conducted.
  • Sixty-two patients requiring enteral nutrition received either oxandrolone (20 mg/day) or placebo for up to 28 days.
  • Nutritional markers (total urinary nitrogen, prealbumin), body composition, and clinical outcomes were monitored.

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Main Results:

  • Both oxandrolone and placebo groups remained highly catabolic, with no significant difference in nitrogen balance or body cell mass changes.
  • Prealbumin levels improved in both groups, but without significant intergroup differences.
  • There were no significant differences in length of hospital stay, ICU stay, or incidence of pneumonia and sepsis.

Conclusions:

  • Oxandrolone at 20 mg/day demonstrated no discernible benefits for nutritional or clinical outcomes in the initial month post-multiple trauma.
  • Further research may be needed to explore different dosages or patient populations.