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The CREM system in human spermatogenesis.

A Peri1, M Serio

  • 1Department of Clinical Physiopathology, University of Florence, Italy. a.peri@dfc.unifi.it

Journal of Endocrinological Investigation
|November 18, 2000
PubMed
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The CREM gene switch from repressors to activators is crucial for human spermatogenesis. Absence of this switch in round spermatids causes infertility and germ cell maturation arrest.

Area of Science:

  • Reproductive biology
  • Molecular endocrinology
  • Spermatogenesis research

Background:

  • Spermatogenesis involves germ cell differentiation regulated by signaling pathways.
  • The cAMP-response element modulator (CREM) transcription factor controls gene expression essential for sperm development.
  • CREM isoforms act as either gene expression activators or repressors.

Purpose of the Study:

  • To investigate the role of CREM gene expression and its isoforms in human spermatogenesis.
  • To determine if the CREM switch observed in mice is present in humans.
  • To explore the association between CREM expression patterns and spermatogenic arrest.

Main Methods:

  • Analysis of CREM gene expression in human germ cells from normospermic men and patients with maturation arrest.

Related Experiment Videos

  • Localization of CREM tau mRNA in specific germ cell types.
  • Comparison of CREM expression patterns between fertile and infertile individuals.

    • Main Results:

    • CREM gene is expressed in human germ cells, with a switch from repressors to activators in normospermic men.
    • CREM tau mRNA is found in the cytoplasm of round spermatids in fertile men.
    • In patients with round spermatid maturation arrest, only CREM repressors are expressed.

    Conclusions:

    • The CREM switch from repressors to activators is vital for normal human spermatogenesis.
    • Absence of the "CREM switch" is linked to testicular patterns of round spermatid maturation arrest.
    • CREM plays a significant role in male fertility and germ cell development.