Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Maternal effect on Parkinson's disease.

R de la Fuente-Fernández1

  • 1Division of Neurology, Hospital A. Marcide, Ferrol, La Coruña, Spain.

Annals of Neurology
|November 18, 2000
PubMed
Summary

Maternal environmental factors may influence Parkinson

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors contributing to caregivers' stress and burden in Parkinson's disease.

Acta neurologica Scandinavica·2014
Same author

DaTscan and Parkinson's disease: DAT binding should not lead to binding decisions in clinical practice.

European journal of neurology·2014
Same author

[Functional neuroimaging in the diagnosis of patients with Parkinsonism: Update and recommendations for clinical use].

Revista espanola de medicina nuclear e imagen molecular·2014
Same author

The powerful pre-treatment effect: placebo responses in restless legs syndrome trials.

European journal of neurology·2012
Same author

Duodenal levodopa/carbidopa infusion therapy in patients with advanced Parkinson's disease leads to improvement in caregivers' stress and burden.

European journal of neurology·2012
Same author

Long-term exposure to duodenal levodopa/carbidopa infusion therapy improves quality of life in relation especially to mobility, activities of daily living, and emotional well-being.

Acta neurologica Scandinavica·2011

Area of Science:

  • Neuroscience
  • Epidemiology
  • Genetics

Background:

  • First-degree relatives of Parkinson's disease (PD) patients show increased PD risk.
  • Previous twin studies have not conclusively demonstrated a genetic basis for PD.
  • A hypothesis suggests maternal environmental exposures could alter ova, predisposing offspring to PD.

Purpose of the Study:

  • To investigate the potential maternal environmental influence on Parkinson's disease development.
  • To examine the correlation between parental age at birth and Parkinson's disease onset.
  • To assess the risk of PD in parents of PD patients compared to controls.

Main Methods:

  • Study included 299 Parkinson's disease patients and 295 control subjects.
  • Analysis focused on the correlation between age at PD onset and maternal/paternal age at birth.
  • Parental PD risk was compared between patient and control groups.

Main Results:

  • A negative correlation was observed between Parkinson's disease onset age and maternal age at birth.
  • No significant correlation was found between PD onset age and paternal age at birth.
  • Parents of Parkinson's disease patients exhibited an elevated risk of developing PD compared to parents of controls.

Conclusions:

  • Findings suggest a significant maternal effect in Parkinson's disease etiology.
  • This maternal effect may be primarily environmental rather than genetic.
  • Further research into maternal exposures and their role in Parkinson's disease pathogenesis is warranted.

Related Experiment Videos