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Influence of age and K, Mg aspartate (Cardilan) on murine haemopoiesis

P Fedorocko1, N O Macková, Z Sándorcínová

  • 1Department of Cellular and Molecular Biology, Faculty of Sciences, P. J. Safárik University, Moyzesova 11, 04167, Kosice, Slovak Republic. fedvox@kosice.upjs.sk

Mechanisms of Ageing and Development
|November 18, 2000
PubMed

Insights

Potassium and magnesium aspartate (Cardilan) supplementation positively impacts aging mice

Area of Science:

  • Hematology
  • Gerontology
  • Nutritional Science

Background:

  • Aging impacts hematopoietic stem cell function and peripheral blood cell counts.
  • The effects of mineral aspartate supplementation on aging hematopoiesis are not well understood.

Purpose of the Study:

  • To investigate the impact of aging on hematopoiesis in ICR mice.
  • To evaluate the effects of short-term and long-term Cardilan (K and Mg salts of aspartic acid) intake on hematopoietic parameters in aging mice.

Main Methods:

  • Assessed bone marrow cellularity, colony-forming cells (GM-CFC), spleen colony-forming units (CFU-S), and erythroid burst-forming units (BFU-E) in aging mice.
  • Administered Cardilan via short-term and long-term drinking protocols to different age groups of mice.
  • Monitored peripheral blood cell counts, including leukocytes and reticulocytes.

Main Results:

  • Aging increased bone marrow CFU-S and BFU-E, while decreasing peripheral leukocytes.
  • Short-term Cardilan intake boosted CFU-S, BFU-E, and reticulocytes in younger aging mice and increased spleen weight/cellularity and peripheral cells in older mice.
  • Long-term Cardilan intake elevated spleen GM-CFC in younger aging mice and reticulocytes in older mice.

Conclusions:

  • K and Mg salts of aspartic acid demonstrate a significant influence on erythropoietic activity.
  • Cardilan supplementation may offer benefits for hematopoietic function during the aging process.

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