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Updated: Jul 11, 2026

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
Published on: July 23, 2012
Recruitment of T cells to the lung in response to antigen challenge
1Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
Abstract:
T-cell recruitment to the lungs is thought to represent a key step in airway allergic inflammation. T cells coordinate and amplify effector functions of antigen-specific and nonspecific proinflammatory cells, such as B cells and eosinophils. The T(H)2 cell, in particular, promotes allergic inflammation through the expression of IL-4, IL-5, and IL-13, proinflammatory cytokines that are important in the induction of B-cell switching and the promotion of eosinophil proliferation and survival. This cytokine profile has been implicated in asthma; elevations in bronchoalveolar lavage IL-4 and IL-5 levels have been observed in asthmatic patients. The recruitment of T(H) cells to the site of allergic inflammation (lung) is the subject of this review.
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