Related Experiment Video

Updated: Aug 10, 2026

Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase
10:23

Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase

Published on: July 23, 2009

[Examination of elastase concentration in the wall of abdominal aortic aneurysms]

J Skóra1, D Janczak, P Barć

  • 1Katedry i Kliniki Chirurgii Naczyniowej AM we Wrocławiu.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|November 18, 2000
PubMed

Insights

Leukocyte elastase (LE) levels are highest in ruptured abdominal aortic aneurysms, indicating a link between PMN-elastase activity and atherosclerosis development.

Area of Science:

  • Biochemistry
  • Vascular Biology
  • Pathology

Context:

  • Abdominal aortic aneurysms (AAAs) and atherosclerosis are significant vascular diseases.
  • Leukocyte elastase (LE) is a protease implicated in inflammatory processes.
  • Understanding LE's role in AAA pathogenesis is crucial for therapeutic development.

Purpose:

  • To investigate the concentration of leukocyte elastase (LE) in serum and aortic walls.
  • To compare LE levels in normal aortas, atherosclerotic aortas, and ruptured/nonruptured AAAs.
  • To explore the relationship between LE levels, aneurysm diameter, and inflammatory genesis.

Summary:

  • This study measured leukocyte elastase (LE) levels in the serum and vessel walls of 87 patients with normal aortas, atherosclerotic aortas, and abdominal aortic aneurysms (AAAs).
  • LE concentrations were highest in ruptured AAAs, followed by nonruptured AAAs, atherosclerotic aortas, and normal aortas.
  • No statistical dependence was found between serum LE levels and other factors, but a connection was established between aneurysm expansion and the inflammatory activity of PMN-elastase in the vessel wall.

Impact:

  • Findings suggest that elevated PMN-elastase activity in the aortic wall is linked to the inflammatory genesis and expansion of atherosclerosis and AAAs.
  • This research highlights LE as a potential biomarker and therapeutic target in vascular inflammatory diseases.
  • The study provides evidence for the inflammatory component in the development and progression of abdominal aortic aneurysms.

More Related Videos

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm08:33

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Published on: August 24, 2019

Advanced Abdominal Aortic Aneurysm Modeling in Mice by Combination of Topical Elastase and Oral ß-aminopropionitrile07:42

Advanced Abdominal Aortic Aneurysm Modeling in Mice by Combination of Topical Elastase and Oral ß-aminopropionitrile

Published on: July 26, 2024

Related Concept Videos

Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...