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[Deafness and Paget's disease].

A Gaucher, M Wayoff, J Pourel

    Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
    |October 1, 1975
    PubMed
    Summary
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    Deafness in Paget's disease presents as mixed or sensorineural types. Surgical and hormonal treatments showed disappointing results, suggesting a focus on preventing this complication.

    Area of Science:

    • Otolaryngology
    • Endocrinology
    • Genetics

    Background:

    • Paget's disease of bone is a chronic disorder characterized by abnormal bone remodeling.
    • Deafness is a potential complication of Paget's disease, particularly with cranial involvement.
    • Two types of deafness associated with Paget's disease are recognized: mixed and sensorineural.

    Purpose of the Study:

    • To investigate the types and prevalence of deafness in patients with Paget's disease.
    • To evaluate the efficacy of surgical and hormonal interventions for deafness in Paget's disease.

    Main Methods:

    • Systematic audiological examinations were performed on 35 hospitalized patients with Paget's disease.
    • Surgical interventions included stapes mobilization and stapedectomy in patients with mixed-type deafness.

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  • Hormonal treatment with calcitonin was administered to a subset of patients.

    • Main Results:

    • 18 cases of deafness were identified among 35 patients (51.4%), with 11 mixed-type and 7 sensorineural-type.
    • Surgical outcomes for mixed-type deafness were disappointing in the long term.
    • Calcitonin treatment showed limited effectiveness, likely due to the advanced stage of the disease and deafness.

    Conclusions:

    • Deafness is a common complication of Paget's disease, manifesting in mixed and sensorineural forms.
    • Current surgical and hormonal treatments for established deafness in Paget's disease are largely ineffective.
    • Hormonal therapy may be beneficial for preventing deafness complications if initiated early in Paget's disease.