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Prognostic factors in patients with surgically resected stages I and II non-small cell lung cancer
A R Jazieh1, M Hussain, J A Howington
1Division of Hematology/Oncology, University of Arkansas for Medical Sciences, Little Rock 72205, USA. jaziehabdulr@exchange.uams.edu
Background:
About one-third to one-half of patients with early stages of non-small cell lung cancer (NSCLC) succumb to their disease. In this study, we attempted to identify prognostic factors that predict outcome in patients with stages I and II NSCLC.
Methods:
A retrospective evaluation of 454 patients with surgically resected stages I and II NSCLC was performed to determine the impact of various clinical, laboratory, and pathological factors on patient outcome such as overall survival (OS) and event-free survival (EFS).
Results:
Patients older than 65 years had shorter EFS and OS than younger patients (p = 0.002). Patients with preoperative hemoglobin less than or equal to 10 g% had shorter EFS and OS compared to patients with a hemoglobin greater than 10 g% (p = 0.001). Expectedly, OS and EFS were shorter in patients with stage II as compared to stage I patients (p < 0.001). In a multivariate analysis, age, hemoglobin level, and stage remain significant predictors for EFS and OS.
Conclusions:
Older age, anemia, and higher stage are important prognostic factors in patients with surgically resected stage I and II NSCLC.