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New peptide labels containing covalently bonded platinum(II) centers as diagnostic biomarkers and biosensors
M Albrecht1, G Rodríguez, J Schoenmaker
1Debye Institute, Department of Metal-Mediated Synthesis, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
Organic Letters
|November 18, 2000
Abstract:
[reaction: see text] Water- and acid-resistant arylplatinum(II) complexes have been covalently bonded to the N-terminus of L-valine, thus providing organometallic biomolecules with excellent stability properties. Owing to the (195)Pt nucleus (I = (1)/(2)), these building blocks are potentially versatile biomarkers (e.g., MRI). Moreover, they display efficient in vitro biosensor characteristics since they detect SO(2) gas selectively and fully reversibly by an instantaneous change of the spectroscopic properties including a diagnostic (195)Pt NMR signal.