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Updated: Aug 15, 2026

RhoC GTPase Activation Assay
Published on: August 22, 2010
Regulation and functions of Rho-associated kinase
M Amano1, Y Fukata, K Kaibuchi
1Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma, 630-0101, Japan.
Abstract:
Remarkable progress has been made in understanding effector molecules of small GTPase Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho-associated kinase appears to mediate a large proportion of the signals from Rho and regulate dynamic reorganization of cytoskeletal proteins, such as stress fiber and focal adhesion formation. Several substrates of Rho-associated kinase have been reported and their cellular functions unraveled. In this review, we focus on the regulation and cellular functions of Rho-associated kinase.
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