[Analysis of interleukin-6 serum concentration in trophoblastic tumors prognosis]
K Drews1, E Nowak-Markwitz, E Brzezińska
1Kliniki Perinatologii AM w Poznaniu.
Objectives:
Our purpose was to estimate the prognosis based on Il-6 concentration in cases of trophoblastic tumors.
Materials And Methods:
The study population was 65 women suffering from hydatiform mola or choriocarcinoma. We divided them into two groups: 30 patients who required only operative management and 35 patients who required operative procedures and additional chemotherapy. The observation period was 6 months. Blood samples were collected every 4 weeks. Concentration of Il-6 was measured in ELISA assay.
Results:
The serum Il-6 concentration was significantly higher in cases of trophoblastic diseases than in the group of healthy women and higher in patients who required chemotherapy after operation (451.0 +/- 88.5 pg/ml), than in patients treated only surgically (257.1 +/- 77.1 pg/ml).
Conclusions:
Patients with hydatiform mola and choriocarcinoma reveal higher concentration of Il-6 than healthy women. It is associated with disease prognosis and allows to determine at the time of establishing a diagnosis, whether a patient can be treated only surgically or requires an additional chemotherapy.