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Culture models of neurodegenerative disease
D A Figlewicz1, L Dong, M Mlodzienski
1Department of Neurology and Neurobiology/Anatomy, University of Rochester Medical Center, New York 14642, USA. Denise_Figlewicz@urmc.rochester.edu
Annals of the New York Academy of Sciences
|November 18, 2000
Abstract:
In order to investigate how mutant SOD1 protein or environmental exogenous stressors lead to the death of motor neurons, we have established several in vitro model systems. We describe some features of the various models in order to demonstrate the advantages and shortcomings of each system.