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Related Experiment Video

Updated: Jul 18, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

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Published on: October 20, 2016

Assessment of left ventricular ejection fraction with quantitative gated SPECT: accuracy and correlation with

E Vallejo1, D P Dione, A J Sinusas

  • 1Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Conn. 06520-8042, USA.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|November 18, 2000
PubMed
Summary

Quantitative gated SPECT (QGS) software provides valuable resting left ventricular ejection fraction (LVEF) assessment. However, QGS LVEF accuracy is impacted by extracardiac activity, image quality, and left ventricular size.

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Published on: May 24, 2021

Area of Science:

  • Nuclear Cardiology
  • Cardiovascular Imaging
  • Medical Physics

Background:

  • Quantitative gated SPECT (QGS) is a common tool for assessing left ventricular ejection fraction (LVEF).
  • Factors influencing QGS LVEF accuracy are not fully understood.
  • This study aimed to define these confounding variables.

Purpose of the Study:

  • To evaluate the accuracy of QGS for determining LVEF across a spectrum of values.
  • To assess the impact of extracardiac activity, count statistics, heart size, and perfusion defects on QGS LVEF accuracy.
  • To compare QGS LVEF at rest versus stress conditions.

Main Methods:

  • Comparison of QGS-derived LVEF with rest first-pass radionuclide angiography (FPRNA) LVEF in 400 gated SPECT studies.
  • Analysis of factors including extracardiac activity, image count density, and left ventricular dimensions.
  • Evaluation of rest versus stress QGS LVEF in the same patients.

Main Results:

  • Overall fair correlation (r=0.66) between QGS and FPRNA LVEF.
  • High extracardiac activity led to software failure in 9% of studies.
  • Improved correlation with higher counts (r=0.81) and abnormal LVEF (r=0.77).
  • Better agreement in larger hearts (larger end-diastolic volumes).
  • Mean QGS LVEF was lower than FPRNA LVEF (54% vs. 58%, P<.0001).
  • No significant difference between rest and stress QGS LVEF.

Conclusions:

  • QGS is a valuable method for resting LVEF assessment.
  • QGS LVEF tends to be underestimated compared to FPRNA.
  • Accuracy is diminished by high extracardiac activity, low count density, and small left ventricular size.