Surgical management of coccidioidomycosis in children

M B Connelly1, J T Zerella

  • 1Department of Pediatric Surgery, Phoenix Children's Hospital, AZ, USA.

Insights

Over half of children hospitalized with Coccidioides immitis infection required surgery, primarily immunocompetent boys with thoracic disease. Pediatric surgeons should be prepared for coccidioidomycosis cases in endemic and nonendemic regions.

Area of Science:

  • Pediatric Surgery
  • Infectious Diseases
  • Mycology

Background:

  • Coccidioides immitis infection (coccidioidomycosis) in children is understudied.
  • An increase in surgical cases for coccidioidomycosis was observed at Phoenix Children's Hospital.
  • This study addresses the surgical management of pediatric coccidioidomycosis.

Purpose of the Study:

  • To review the surgical management of children diagnosed with Coccidioides immitis infection.
  • To analyze the characteristics and outcomes of pediatric patients undergoing surgery for coccidioidomycosis.

Main Methods:

  • Retrospective review of medical records for children hospitalized with confirmed coccidioidomycosis from 1994 to 1999.
  • Data collected included age, gender, race, immune status, laboratory findings, surgical procedures, and patient outcomes.
  • Analysis focused on the subset of patients who underwent surgical intervention.

Main Results:

  • Out of 39 pediatric patients with coccidioidomycosis, 21 (54%) required a total of 49 operations.
  • The majority of affected children were boys (72%).
  • Thoracic procedures were the most common type of surgery (19 cases).

Conclusions:

  • More than half of hospitalized children with coccidioidomycosis needed surgical intervention.
  • The typical patient requiring surgery was an immunocompetent boy with thoracic involvement.
  • Pediatric surgeons in both endemic and nonendemic areas should anticipate and manage coccidioidomycosis.
Abstract

Related Concept Videos

Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic sinusitis...
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...