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Related Experiment Videos

Subareolar breast cancers.

C Gajdos1, P I Tartter, I J Bleiweiss

  • 1Department of Surgery, Mount Sinai Medical Center, New York, New York, USA.

American Journal of Surgery
|November 21, 2000
PubMed
Summary
This summary is machine-generated.

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Breast-conserving surgery for subareolar cancers is feasible with radiation therapy. Clinical nipple-areola complex involvement predicts local recurrence risk in breast conservation patients without radiation.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Breast Cancer Research

Background:

  • Subareolar cancers frequently involve the nipple-areola complex (NAC), leading to poor cosmetic outcomes with lumpectomy.
  • Breast conservation surgery (BCS) is increasingly applied to these cases.

Purpose of the Study:

  • To evaluate the outcomes of BCS for subareolar cancers.
  • To identify factors predicting recurrence in patients with subareolar cancers.

Main Methods:

  • Retrospective review of 95 patients with subareolar cancers treated between 1979 and 1998.
  • Analysis of pathologic findings, treatment modalities (mastectomy vs. BCS), and oncologic outcomes.
  • Univariate and multivariate analyses to determine predictors of NAC involvement and recurrence.

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Main Results:

  • Clinical NAC involvement, presentation, and tumor size were associated with pathologic NAC involvement.
  • In multivariate analysis, only clinical NAC involvement predicted pathologic NAC involvement.
  • For BCS patients, radiation therapy, clinical, and pathologic NAC involvement predicted local recurrence.
  • Clinical NAC involvement was the sole predictor of local recurrence in BCS patients after accounting for radiation therapy.

Conclusions:

  • Subareolar cancers can be treated with BCS if adjuvant radiation therapy is administered.
  • Clinical NAC involvement is a significant risk factor for local recurrence in BCS patients not receiving radiation.