Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pathophysiology of pain].

A Eschalier1, F Coudore, G Pickering

  • 1INSERM EPI 9904, Laboratoire de Pharmacologie Médicale, Faculté de Médecine-CHU, Clermont-Ferrand. alain.eschalier@u-clermont1.fr

Neuro-Chirurgie
|November 21, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential Cell Cohesiveness Expressed by Prespore and Prestalk Cells of Dictyostelium discoideum.

Differentiation; research in biological diversity·2020
Same author

Pharmacological and non-pharmacological treatments for neuropathic pain: Systematic review and French recommendations.

Revue neurologique·2020
Same author

Management of neuropathic pain induced by surgery: Review of the literature by a group of experts specialized in pain management, anesthesia and surgery.

Journal of visceral surgery·2019
Same author

Dextromethorphan Analgesia in a Human Experimental Model of Hyperalgesia.

Anesthesiology·2019
Same author

Is quantitative sensory testing helpful in the management of oxaliplatin neuropathy? a two-year clinical study.

Cancer treatment and research communications·2018
Same author

Prescription opioid analgesic use in France: Trends and impact on morbidity-mortality.

European journal of pain (London, England)·2018

Understanding pain involves recognizing peripheral and central changes, including neuroplasticity and specific mediators. Advances in pain pathophysiology aid in developing novel analgesic drugs.

Area of Science:

  • Neuroscience
  • Pain Medicine
  • Pharmacology

Context:

  • Pain perception involves complex peripheral and central nervous system mechanisms.
  • Nociceptive pain involves nociceptor sensitization and secondary central sensitization.
  • Neuropathic pain mechanisms differ, involving afferent fiber alterations and ectopic discharges.

Purpose:

  • To elucidate the neurobiological underpinnings of nociceptive and neuropathic pain.
  • To explore the roles of various mediators and neuroplasticity in pain signaling.
  • To connect advancements in pain pathophysiology to the development of analgesic therapies.

Summary:

  • Pain pathophysiology involves peripheral (nociceptor sensitization, neurogenic inflammation) and central (spinal cord changes, NMDA receptor involvement) mechanisms.

Related Experiment Videos

  • Neuropathic pain features ectopic discharges, fiber sprouting, and altered ion channel activity.
  • Neuroplasticity and specific mediators like substance P are key to understanding pain states.

    • Impact:

    • Enhanced understanding of pain mechanisms informs the development of novel analgesic drugs.
    • Identifies targets for therapeutic intervention in chronic pain conditions.
    • Provides a foundation for discovering drugs with original mechanisms of action.