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Related Experiment Videos

Chorionic villus sampling before multifetal pregnancy reduction.

K A Eddleman1, J L Stone, L Lynch

  • 1Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai Medical Center, New York, New York, USA.

American Journal of Obstetrics and Gynecology
|November 21, 2000
PubMed
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Chorionic villus sampling before multifetal pregnancy reduction is technically feasible and accurate. This procedure does not increase pregnancy loss rates after reduction, demonstrating its safety in high-risk pregnancies.

Area of Science:

  • Maternal-Fetal Medicine
  • Reproductive Genetics

Background:

  • Multifetal pregnancy reduction is a procedure to manage high-order multiples.
  • Chorionic villus sampling (CVS) is a diagnostic test for fetal genetic abnormalities.

Purpose of the Study:

  • To assess the technical feasibility and accuracy of CVS prior to multifetal pregnancy reduction.
  • To evaluate if CVS increases pregnancy loss after multifetal pregnancy reduction.

Main Methods:

  • Retrospective analysis of 1183 patients undergoing multifetal pregnancy reduction.
  • CVS attempted in 86 patients before reduction.
  • Comparison of pregnancy loss rates between patients with and without pre-reduction CVS.

Main Results:

  • CVS success rate was 98.8% (85/86 patients).

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  • Fetal karyotype accuracy was high (99.4% sampled).
  • Pregnancy loss rate after reduction was low (1.4% in the CVS group).

    • Conclusions:

    • CVS before multifetal pregnancy reduction is technically feasible and accurate.
    • The procedure is safe and does not elevate post-reduction pregnancy loss risk.