Related Experiment Video

Updated: Oct 10, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Lipoprotein(a) in coronary heart disease: a case-control study

R Gupta1, S Kastia, S Rastogi

  • 1Department of Medicine, Monilek Hospital, Jaipur.

Indian Heart Journal
|November 21, 2000
PubMed

Insights

Elevated lipoprotein(a) levels are significantly higher in coronary heart disease patients compared to controls. This finding holds true for both younger and older individuals, indicating its importance in heart disease risk.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Biochemistry

Background:

  • Coronary heart disease (CHD) remains a leading cause of mortality worldwide.
  • Lipoprotein(a) [Lp(a)] is an emerging risk factor for atherosclerotic cardiovascular diseases.
  • Understanding the role of Lp(a) in CHD is crucial for risk stratification and management.

Purpose of the Study:

  • To investigate the association between lipoprotein(a) levels and coronary heart disease.
  • To compare Lp(a) concentrations in newly diagnosed CHD patients versus healthy controls.

Main Methods:

  • A case-control study involving 48 CHD patients and 23 controls.
  • Clinical history and biochemical examinations were performed.
  • Lipoprotein(a) levels were quantified using a latex-enhanced immunoturbidimetric method.

Main Results:

  • No significant differences were observed in traditional risk factors like diabetes, hypertension, smoking, or dietary intake between cases and controls.
  • Standard lipid parameters (cholesterol, LDL-C, HDL-C, triglycerides) and lipid ratios were similar between groups.
  • Mean lipoprotein(a) levels were significantly higher in CHD patients (11.95 mg/dL) compared to controls (6.68 mg/dL) (p=0.041).
  • Elevated Lp(a) was observed in CHD patients across all age groups, including those under and over 50 years.
  • A higher prevalence of high Lp(a) levels (≥20 mg/dL) was noted in CHD patients (31.3%) versus controls (13.0%).
  • The comprehensive lipid tetrad index, incorporating Lp(a), was also higher in CHD cases.

Conclusions:

  • Lipoprotein(a) is significantly elevated in coronary heart disease patients, independent of traditional risk factors.
  • Elevated Lp(a) levels are a significant marker in both younger and older CHD patients.
  • Lipoprotein(a) may serve as an independent predictor of coronary heart disease risk.

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...