Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunomodulating activity of MDMA.

R Pacifici1, P Zuccaro, M Farré

  • 1Clinical Biochemistry Department, Istituto Superiore di Sanità, Roma, Italy.

Annals of the New York Academy of Sciences
|November 21, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ewe's diet during gestation and lactation affects ready-to-eat meat from light lambs.

Animal : an international journal of animal bioscience·2021
Same author

Effects of sous vide vs grilling methods on lamb meat colour and lipid stability during cooking and heated display.

Meat science·2020
Same author

Maternal grazing on stubble and Mediterranean shrubland improves meat lipid profile in light lambs fed on concentrates.

Animal : an international journal of animal bioscience·2017
Same author

Atomically resolved phase transition of fullerene cations solvated in helium droplets.

Nature communications·2016
Same author

Use of dietary rosemary diterpenes to inhibit rancid volatiles in lamb meat packed under protective atmosphere.

Animal : an international journal of animal bioscience·2016
Same author

Helicobacter pylori second-line rescue therapy with levofloxacin- and bismuth-containing quadruple therapy, after failure of standard triple or non-bismuth quadruple treatments.

Alimentary pharmacology & therapeutics·2015

MDMA (3,4-methylenedioxymethamphetamine) use significantly impairs immune function in both rats and humans, potentially increasing disease risk. This drug acts as a chemical stressor, activating stress response systems and altering immune cell activity.

Area of Science:

  • Immunology
  • Neuroendocrinology
  • Pharmacology

Background:

  • 3,4-methylenedioxymethamphetamine (MDMA) acts as a chemical stressor, inducing neurochemical and endocrine changes.
  • Stressful stimuli are known to suppress immune function and alter immune cell distribution.
  • MDMA's effects on the immune system and stress response pathways require detailed investigation.

Purpose of the Study:

  • To investigate the impact of MDMA on immune function and stress response.
  • To compare MDMA's effects in a rat model and in humans.
  • To elucidate the mechanisms underlying MDMA-induced immune alterations.

Main Methods:

  • In vitro and in vivo studies in rats and humans.
  • Assessed immune cell function (T-cells, NK cells, macrophages) and lymphocyte proliferation.

Related Experiment Videos

  • Measured plasma corticosterone and cortisol concentrations.

    • Main Results:

    • MDMA exposure modulated immune cell function in vitro.
    • In rats, MDMA suppressed lymphocyte proliferation and decreased circulating lymphocytes, accompanied by increased corticosterone.
    • In humans, MDMA caused immune dysfunction, decreased CD4+ T-cells, and increased NK cells, with elevated cortisol, suggesting HPA axis and SNS activation.

    Conclusions:

    • MDMA ingestion can lead to significant immune system dysfunction.
    • MDMA activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS).
    • MDMA use poses a potential health hazard, increasing the risk of immune system-related diseases.