Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Consulting the source code: prospects for gene-based medical diagnostics.

U Landegren1

  • 1Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala, Sweden. ulf.landegren@genpat.uu.se

Journal of Internal Medicine
|November 22, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protein biomarker validation via proximity ligation assays.

Biochimica et biophysica acta·2013
Same author

Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion.

Oncogene·2012
Same author

Profiling protein expression and interactions: proximity ligation as a tool for personalized medicine.

Journal of internal medicine·2010
Same author

Single-nucleotide sequence discrimination in situ using padlock probes.

Current protocols in cytometry·2008
Same author

Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations.

Journal of medical genetics·2008
Same author

Beta-globin mRNA increases rapidly during erythropoietin treatment.

Scandinavian journal of clinical and laboratory investigation·2003
Same journal

Patients with hereditary hemorrhagic telangiectasia have significantly reduced overall survival-And likely by a greater magnitude than we realize.

Journal of internal medicine·2026
Same journal

Social jet lag is associated with incident cardiovascular disease independent of sleep duration and cardiac genetic risk.

Journal of internal medicine·2026
Same journal

Multicenter validation of a severity index model for predicting postoperative acute kidney injury.

Journal of internal medicine·2026
Same journal

The changing epidemiology of human type 2 diabetes-associated atherosclerosis: Pathophysiological mechanisms and emerging treatment possibilities.

Journal of internal medicine·2026
Same journal

Angiopoietin-like protein 3 complete and partial deficiency markedly accelerates apolipoprotein B48 and B100 metabolism in triglyceride-rich lipoproteins in humans.

Journal of internal medicine·2026
Same journal

Authors' reply: Myasthenia gravis following the initiation of statin therapy.

Journal of internal medicine·2026
See all related articles

Gene-based diagnostics are becoming more accessible due to advances in genetic information and analysis. This enables identification of genetic factors for disease diagnosis and therapy response, impacting views on health and genetics.

Area of Science:

  • Genetics
  • Medical Diagnostics
  • Genomic Medicine

Background:

  • Gene-based diagnostics have faced slow adoption in routine medical practice.
  • Recent advancements are accelerating the integration of genetic information into healthcare.

Purpose of the Study:

  • To highlight the key developments driving the adoption of gene-based diagnostics.
  • To discuss the implications of increased genetic diagnostic capabilities on perceptions of health and normality.

Main Methods:

  • Analysis of emerging trends in genetic information availability (human and pathogen genomes).
  • Identification of diagnostic genetic factors, including mutations, DNA variants, and copy number alterations.
  • Assessment of improved methodologies for genetic analysis in clinical settings.

Related Experiment Videos

Main Results:

  • Rapid availability of comprehensive human and pathogen genetic information.
  • Identification of numerous genetic factors (mutations, variants, copy number alterations) with diagnostic value for diseases and therapy response.
  • Improved genetic analysis techniques make these factors clinically accessible.

Conclusions:

  • Gene-based diagnostics are poised for wider clinical implementation, driven by data availability and analytical improvements.
  • The expansion of genetic diagnostics may reshape definitions of health, normality, and human genetic plasticity.
  • These advancements necessitate ongoing discussions regarding fundamental aspects of genetics.