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Synthesis and evaluation of 4-deacetoxyagosterol A as an MDR-modulator
N Murakami1, M Sugimoto, M Morita
1Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Bioorganic & Medicinal Chemistry Letters
|November 22, 2000
Abstract:
4-Deacetoxyagosterol A was synthesized from ergosterol by utilizing reductive regioselective epoxy cleavage as a key reaction. This synthesized congener of agosterol A, a spongean MDR-modulator. showed similar MDR-modulating activity against KB CV-60 cells overexpressing MRP.