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Studies on poly(propylene fumarate-co-ethylene glycol) based bone cement
M Jayabalan1, V Thomas, P K Sreelatha
1Polymer Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India. jaybalan@sctimst.ker.nic.in
Bio-Medical Materials and Engineering
|November 22, 2000
Summary
Poly(propylene fumarate-co-ethylene glycol) random (PPF-1) copolymer, when formulated into bone cement with n-vinyl pyrrolidone (n-VP) and hydroxyapatite (HAP), exhibits favorable setting and degradation properties for bone defect repair.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Orthopedic Engineering
Background:
- Development of advanced bone cements is crucial for orthopedic applications.
- Poly(propylene fumarate-co-ethylene glycol) (PPF) copolymers offer tunable properties for biomaterial design.
- Understanding the structure-property relationships of PPF copolymers is essential for optimizing bone cement formulations.
Purpose of the Study:
- To synthesize and characterize random (PPF-1) and block (PPF-2) poly(propylene fumarate-co-ethylene glycol) copolymer oligomers.
- To evaluate the setting and swelling characteristics of PPF-1 and PPF-2 copolymers with n-vinyl pyrrolidone (n-VP).
- To develop and assess a novel bone cement composite based on PPF-1, n-VP, and hydroxyapatite (HAP) for orthopedic applications.
Main Methods:
- Synthesis of random (PPF-1) and block (PPF-2) copolymer oligomers.
- Comparative analysis of setting temperature, setting time, and swelling characteristics of PPF-1 and PPF-2 with n-VP.
- Formulation of bone cement using PPF-1, n-VP, and hydroxyapatite (HAP).
- In vitro degradation studies in Ringer's solution and phosphate-buffered saline (PBS).
- Mechanical property testing (compressive strength, modulus) and bone-binding strength assessment.
Main Results:
- PPF-1 exhibited lower setting temperature and time, higher swelling coefficient, and lower crosslink density compared to PPF-2.
- The PPF-1/n-VP/HAP bone cement showed reduced weight loss and deformation during in vitro degradation.
- While mechanical properties decreased upon aging due to PEG hydration, the bone-binding strength was comparable to existing bone cements.
- The PPF-1 based bone cement demonstrated adequate mechanical properties and bone-binding capabilities.
Conclusions:
- PPF-1/n-VP/HAP bone cement possesses favorable setting and degradation characteristics.
- The developed bone cement shows potential for use as a scaffold in correcting bone defects.
- Further investigation into mechanical property stability during aging is warranted for clinical translation.