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Related Experiment Videos

Establishing a left-right axis in the embryo.

A K Ryan1, J C Izpisúa Belmonte

  • 1Department of Medicine, University of California San Diego, La Jolla 92093-0648, USA. aimee.ryan@muhe.mcgill.ca

IUBMB Life
|November 22, 2000
PubMed
Summary

Vertebrates have conserved left-right body asymmetries crucial for organ function. This review covers molecular mechanisms that establish the left-right axis during embryonic development.

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Area of Science:

  • Developmental Biology
  • Embryogenesis
  • Organogenesis

Background:

  • Vertebrates display conserved left-right asymmetries in internal organ placement.
  • These asymmetries are vital for normal physiological function.
  • Left-right organ positioning relies on establishing a defined left-right axis during embryogenesis.

Purpose of the Study:

  • To review molecular components involved in initiating and maintaining the left-right axis.
  • To discuss the function of these molecules in establishing left-right asymmetries.

Main Methods:

  • Literature review of molecular mechanisms.
  • Analysis of gene and protein functions in axis formation.

Main Results:

  • Identification of key molecular players in left-right axis determination.
  • Understanding the pathways regulating situs inversus and normal asymmetry.

Conclusions:

  • The formation of the left-right axis is a complex process involving multiple molecular signals.
  • Further research into these pathways can elucidate developmental disorders related to asymmetry.

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