Related Experiment Video
Updated: Sep 2, 2026

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
Published on: October 18, 2013
Abstract:
The author recalls the main stages of biosynthesis of proteins based on molecular pathology : transcription of DNA into messenger RNA, the genetic code, translation of protein molecules and regulation of their synthesis. Examples are then given of qualitative and quantitative disturbances. Qualitative disturbances with synthesis of abnormal proteins, or protein diseases of protein structure, together with their consequences. Quantitative disorders, with modified synthesis of normal proteins, result very often from abnormalities of structural genes, but also from abnormalities of transcription or translation. The author considers, in conclusion, pathological situations based on molecular abnormalities for mutations occur at random and it may be possible to correct them by genetic manipulation.
Related Concept Videos
DNA Microarrays
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
IP3/DAG Signaling Pathway
Modern Molecular Taxonomy
Applications of Molecular Taxonomy

