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Published on: August 16, 2018
Sesquiterpenes from the basidiomycete Omphalotus illudens
T C McMorris1, R Lira, P K Gantzel
1Department of Chemistry and Biochemistry and Department of Pathology, University of California, San Diego, La Jolla, California 92093-0506, USA.
Researchers isolated a new sesquiterpene, omphadiol, from Omphalotus illudens cultures. Known compounds like illudosin were also identified, with structures confirmed by advanced analytical methods.
Area of Science:
- Natural Products Chemistry
- Mycology
- Organic Chemistry
Background:
- Omphalotus illudens is a fungus known to produce bioactive secondary metabolites.
- Sesquiterpenes are a class of terpenes derived from six isoprene units.
Purpose of the Study:
- To isolate and characterize novel compounds from Omphalotus illudens.
- To elucidate the chemical structures of isolated metabolites.
Main Methods:
- Cultivation of Omphalotus illudens.
- Extraction and purification of fungal metabolites.
- Structure elucidation using Mass Spectrometry (MS), Nuclear Magnetic Resonance (NMR) spectroscopy, and X-ray crystallography.
Main Results:
- Isolation and identification of a new sesquiterpene, named omphadiol (4).
- Co-isolation of known compounds, including illudosin (1).
- Confirmation of chemical structures through comprehensive spectroscopic and crystallographic analyses.
Conclusions:
- Omphalotus illudens is a source of novel sesquiterpenes.
- Omphadiol represents a new addition to the known metabolites of this fungal species.
- The structural determination provides a basis for further investigation into the biological activities of omphadiol.
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