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Decreased striatal dopaminergic innervation in REM sleep behavior disorder
R L Albin1, R A Koeppe, R D Chervin
1Department of Neurology, University of Michigan, Ann Arbor, USA. ralbin@umich.edu
Neurology
|November 23, 2000
Abstract:
REM sleep behavior disorder (RBD) is a possible herald of neurodegenerative disorders with parkinsonism. The authors determined the density of striatal dopaminergic terminals with [11C]dihydrotetrabenazine PET in six elderly subjects with chronic idiopathic RBD and 19 age-appropriate controls. In subjects with RBD, there were significant reductions in striatal [11C]dihydrotetrabenazine binding, particularly in the posterior putamen.