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Related Experiment Videos

Somatostatin and behaviour: the need for genetically engineered models.

C Viollet1, C Videau, J Epelbaum

  • 1Unité 159 Inserm, IFR BROCA -Sainte ANNE, Paris, France.

Journal of Physiology, Paris
|November 23, 2000
PubMed
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Somatostatin peptides regulate pituitary hormone secretion. Recent development of pharmacological tools and animal models aims to uncover their behavioral functions.

Area of Science:

  • Neuroendocrinology
  • Molecular Pharmacology
  • Behavioral Neuroscience

Background:

  • Somatostatin (SRIF) is a neurohormone inhibiting pituitary Growth Hormone (GH) secretion.
  • Mammals express somatostatin-14, somatostatin-28, and cortistatins, binding to five somatostatin receptors (sst1-5).
  • The precise behavioral functions of somatostatin-related peptides remain largely unknown.

Purpose of the Study:

  • To review recent advancements in pharmacological tools and animal models for somatostatin research.
  • To facilitate the elucidation of somatostatin-related peptide functions.

Main Methods:

  • Focus on the development of selective somatostatin receptor antagonists.
  • Discussion of novel animal models for studying somatostatin peptide roles.

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Main Results:

  • Progress in creating specific pharmacological tools to target somatostatin receptors.
  • Emergence of new animal models offering better insights into somatostatin functions.

Conclusions:

  • Improved pharmacological tools and animal models are crucial for understanding somatostatin peptide-mediated behaviors.
  • Future research can now better investigate the physiological and behavioral roles of somatostatin signaling.