Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuropathologic substrates of ischemic vascular dementia.

H V Vinters1, W G Ellis, C Zarow

  • 1Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California 90095-1732, USA.

Journal of Neuropathology and Experimental Neurology
|November 23, 2000
PubMed
Summary

Ischemic vascular dementia (IVD) involves multiple brain lesions causing cognitive decline. Autopsy findings reveal lacunar infarcts and microinfarcts are common in IVD patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Baseline Findings of PreventE4: A Double-Blind Placebo Controlled Clinical Trial Testing High Dose DHA in APOE4 Carriers before the Onset of Dementia.

The journal of prevention of Alzheimer's disease·2023
Same author

Author Correction: Universal DNA methylation age across mammalian tissues.

Nature aging·2023
Same author

Universal DNA methylation age across mammalian tissues.

Nature aging·2023
Same author

Improving the solubility of pseudo-hydrophobic Alzheimer's Disease medicinal chemicals through co-crystal formulation.

bioRxiv : the preprint server for biology·2023
Same author

Review: Vascular dementia: clinicopathologic and genetic considerations.

Neuropathology and applied neurobiology·2018
Same author

Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models.

Translational psychiatry·2017

Area of Science:

  • Neurology
  • Pathology
  • Gerontology

Background:

  • Ischemic vascular dementia (IVD) is characterized by progressive cognitive and memory impairment due to multiple ischemic brain lesions.
  • These lesions can exacerbate neuropsychological deficits in Alzheimer disease (AD).
  • Cerebral microvascular disease is a key factor in many dementia cases.

Purpose of the Study:

  • To review neuropathological findings in 20 patients with diagnosed IVD.
  • To correlate vascular pathologies with cognitive impairment.
  • To propose a method for quantifying ischemic burden in dementia.

Main Methods:

  • Autopsy examination of the central nervous system from 20 patients (aged 68-92).
  • Longitudinal investigation including structural, neurochemical, neuroimaging, and neuropsychological assessments.

Related Experiment Videos

  • Analysis of neuropathological abnormalities such as infarcts and vascular changes.

    • Main Results:

    • Lacunar infarcts and microinfarcts were the most common abnormalities, found in over half of the patients.
    • Evidence of hippocampal injury was present in 11/20 patients.
    • Severe atherosclerosis and arterio/arteriolosclerosis correlated with multiple lacunar infarcts.

    Conclusions:

    • IVD is associated with widespread small ischemic lesions throughout the CNS.
    • Quantifying ischemic and parenchymal disease burden may aid in understanding dementia syndromes.
    • Neuropathological features of both familial and sporadic vascular dementia are relevant.