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Geminiviruses and the plant cell cycle.

C Gutierrez1

  • 1Centro de Biologá Molecular 'Severo Ochoa', Consejo Superior de Investigaciones Cientificas, Universidad Autónoma de Madrid, Cantoblanco, Spain. cgutierrez@cbm.uam.es

Plant Molecular Biology
|November 23, 2000
PubMed
Summary

Geminiviruses, small plant DNA viruses, impact host gene expression and DNA replication. They interact with plant cell cycle proteins, particularly retinoblastoma-related (RBR) proteins, through distinct mechanisms.

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Area of Science:

  • Plant virology
  • Molecular biology
  • Cell cycle regulation

Background:

  • Geminiviruses are small DNA viruses infecting diverse plant species.
  • Viral proteins regulate geminivirus replication, transcription, and host gene expression.
  • Cellular DNA replication proteins, like PCNA, accumulate in infected cells.

Purpose of the Study:

  • To explore the interaction between geminiviruses and plant cell cycle control pathways.
  • To elucidate the mechanisms by which viral proteins influence host DNA replication and cell cycle progression.
  • To discuss the role of retinoblastoma-related (RBR) proteins in geminivirus infection.

Main Methods:

  • Analysis of viral protein interactions with host factors.
  • Investigation of cell cycle regulation interference by viral proteins.
  • Comparative study of different geminivirus genera (Mastrevirus, Begomovirus, Curtovirus).

Main Results:

  • Geminivirus Rep proteins influence cellular gene expression and DNA replication.
  • Viral proteins interact with plant retinoblastoma-related (RBR) proteins.
  • Two distinct mechanisms of RBR interaction exist: one with an LxCxE motif (e.g., RepA) and one without (e.g., Rep).

Conclusions:

  • Geminiviruses have evolved sophisticated strategies to manipulate host cell cycle machinery for replication.
  • Understanding these interactions provides insights into both viral pathogenesis and plant cell biology.
  • The identified mechanisms highlight the diverse evolutionary paths geminiviruses take to control host processes.

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