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Increase of macrophage migration inhibitory factor in sera of patients with iridocyclitis
N Kitaichi1, S Kotake, Y Mizue
1Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Japan.
The British Journal of Ophthalmology
|November 25, 2000
Abstract
Aims:
To determine whether macrophage migration inhibitory factor (MIF) levels were increased in sera of the patients with iridocyclitis.
Methods:
Sera were obtained from 41 patients with acute iridocyclitis, 13 patients with chronic iridocyclitis, and 44 healthy control subjects. MIF levels were determined by a human MIF ELISA.
Results:
The average levels of MIF in the sera of patients with both acute and chronic iridocyclitis were significantly higher than that of healthy subjects.
Conclusion:
Uveitis induces the elevation of serum MIF, which may affect various inflammatory symptoms in uveitis.