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Detection of a group of risk factors in coronary disease using a new carriership analysis approach
L F Watelet1, A J Moss, W Zareba
1Department of Biostatistics, University of Rochester Medical Center, New York 14642, USA.
Abstract:
Carriership analysis is a statistical approach for detecting the average increase in risk (hazard ratio) for adverse time-dependent events per number of prespecified phenotypic or genotypic risk factors carried by subjects in limited-sized populations. This carriership approach was applied to phenotypic risk factor analysis in a postinfarction population, and simulated genetic modeling was performed to show how carriership analysis could be used to identify a group of oligogenic factors in common polygenic disorders.
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