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Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Introduction01:26

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Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...
Type I Diabetes I: Introduction01:12

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Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...

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Insulin-Dependent Diabetic Mastopathy: A Case Report.

Kuno1, Fukutomi, Akashi-Tanaka

  • 1Department of Surgical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104, Japan.

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Diabetic fibrous mastopathy can mimic breast cancer in women with diabetes mellitus. Histopathology confirmed this benign condition, highlighting the importance of accurate diagnosis in diabetic patients presenting with breast lumps.

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Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Diabetic fibrous mastopathy is a rare, benign breast condition affecting individuals with long-standing diabetes mellitus.
  • Clinical presentation can include stony-hard breast lumps, often leading to suspicion of malignancy.
  • Imaging findings may overlap with those of breast cancer, necessitating careful evaluation.

Purpose of the Study:

  • To report a case of diabetic fibrous mastopathy that clinically mimicked breast cancer.
  • To emphasize the diagnostic challenges and histopathological features of this condition.

Main Methods:

  • Case presentation of a 55-year-old woman with insulin-dependent diabetes mellitus and palpable breast lumps.
  • Diagnostic workup included mammography and ultrasonography.
  • Excisional biopsy and subsequent histopathological examination of the breast lump.

Main Results:

  • Mammography showed a highly-dense mass shadow, and ultrasonography detected suspicious hypoechoic lesions with acoustic shadows.
  • Histopathological examination revealed dense fibrosis with lymphocytic infiltration around lobules, characteristic of diabetic fibrous mastopathy.
  • The condition clinically simulated breast cancer, but was confirmed as benign.

Conclusions:

  • Diabetic fibrous mastopathy can present with imaging findings suggestive of malignancy.
  • Accurate histopathological diagnosis is crucial for differentiating diabetic fibrous mastopathy from breast cancer.
  • Awareness of this condition is important for clinicians managing diabetic patients with breast abnormalities.