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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
Prognostic Relevance of Tn Expression in Breast Cancer
1Department of Surgery II, Fukuchima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan.
Breast Cancer (Tokyo, Japan)
|November 25, 2000
Summary
Breast cancer patients with Tn antigen expression had poorer survival rates. This study found Tn antigen expression is a significant prognostic factor, though its impact diminished in multivariate analysis for overall survival.
Area of Science:
- Oncology
- Glycobiology
- Cancer Research
Background:
- Aberrant glycosylation is a hallmark of carcinoma-associated mucins.
- The Tn antigen, a specific carbohydrate epitope, is implicated in cancer progression.
Purpose of the Study:
- To investigate the prognostic relevance of Tn antigen expression in breast cancer tissue.
- To evaluate the association between Tn antigen expression and clinical parameters.
Main Methods:
- Retrospective analysis of immunohistochemical staining for Tn antigen in 219 breast cancer tissues.
- Positive staining defined as ≥10% of the lesion.
- Correlation with patient age, nodal status, estrogen receptor status, menopausal status, and tumor size.
Main Results:
- Tn antigen expression was observed in 45% of breast cancer lesions.
- A significant association was found between Tn antigen expression and tumor size.
- Patients negative for Tn antigen exhibited significantly better survival rates compared to positive cases.
Conclusions:
- Tn antigen expression is a significant prognostic factor in breast cancer.
- While initially significant, its prognostic value was not maintained in multivariate analysis.
- Further research is needed to elucidate the biological role of Tn expression in breast cancer.
