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Sentinel Node Biopsy in Breast Cancer Patients with Clinically Negative Lymph-Nodes
1Departments of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka 537-8511, Japan.
Breast Cancer (Tokyo, Japan)
|November 25, 2000
Summary
Dye-guided sentinel node biopsy is effective for breast cancer staging in patients with clinically negative nodes. This method accurately identifies metastatic nodes, aiding treatment decisions.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Accurate staging is crucial for breast cancer treatment.
- Sentinel lymph node biopsy (SLNB) is a standard procedure for staging.
- Identifying sentinel nodes in clinically node-negative patients requires reliable techniques.
Purpose of the Study:
- To assess the utility of indocyanin green dye-guided SLNB in breast cancer.
- To determine the anatomical location of sentinel nodes in the axilla.
Main Methods:
- Indocyanin green dye-guided SLNB was performed in 150 breast cancer patients with clinically negative nodes.
- Complete axillary dissection followed SLNB.
- Sentinel nodes and axillary nodes were analyzed separately for metastases.
Main Results:
- Sentinel nodes were identified in 76.7% of patients.
- Metastases were confined to the sentinel node in 45.2% of positive cases.
- High concordance (96.5%) was observed between sentinel and axillary node status.
Conclusions:
- Indocyanin green dye-guided SLNB is a feasible technique with good detection rates for breast cancer.
- Sentinel nodes are predominantly located near the lateral pectoralis minor muscle and cranial to the intercostobrachial nerve.