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New Prognostic Factors Associated with Long-term Survival in Node-Negative Breast Cancer Patients
1Departments of Surgery II, School of Medicine, Tokoy Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Breast Cancer (Tokyo, Japan)
|November 25, 2000
Summary
Proliferating cell nuclear antigen (PCNA) and angiogenesis are key new prognostic factors for node-negative breast cancer patients, significantly predicting relapse-free and overall survival.
Area of Science:
- Oncology
- Pathology
- Cancer Research
Background:
- Node-negative breast cancer prognosis relies on various clinicopathological factors.
- Accurate prediction of relapse-free survival (RFS) and overall survival (OS) is crucial for long-term patient management.
- Identifying novel prognostic markers can improve risk stratification.
Purpose of the Study:
- To evaluate the prognostic value of angiogenesis and proliferating cell nuclear antigen (PCNA) alongside conventional factors.
- To determine their role in predicting RFS and OS in Japanese patients with node-negative breast cancer.
- To establish the independent predictive power of these markers.
Main Methods:
- Study included 200 Japanese patients with node-negative breast cancer.
- Investigated nine factors: angiogenesis, PCNA, tumor size, histological grade (HG), necrosis, lymphatic vessel invasion (LVI), and others.
- Follow-up median of 10 years (range 1-20) for survival analysis.
Main Results:
- Univariate analysis identified PCNA, tumor size, HG, angiogenesis, and LVI as significant predictors of RFS/OS.
- Multivariate analysis confirmed clinical tumor size, angiogenesis, PCNA, and HG as independent prognostic factors for RFS.
- PCNA and clinical tumor size were significant independent factors for OS; angiogenesis was borderline significant.
Conclusions:
- Proliferating cell nuclear antigen (PCNA) and angiogenesis are significant new prognostic factors in node-negative breast cancer.
- These markers, along with tumor size and HG, improve the prediction of long-term survival outcomes.
- The findings offer enhanced tools for risk assessment in this patient group.
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