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Recent Progress in Breast Conserving Therapy: From Experiences in Japan
1Departments of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka 537, Japan.
Breast Cancer (Tokyo, Japan)
|December 20, 1996
Summary
Breast conserving therapy (BCT) is increasingly used for breast cancer. Positive surgical margins and lack of radiation therapy significantly increase recurrence risk in patients undergoing BCT.
Area of Science:
- Oncology
- Surgical Oncology
- Radiation Oncology
Background:
- Breast conserving therapy (BCT) usage has risen in Japan since 1994.
- Published data indicate 10-27% of BCT patients experience positive surgical margins.
- Current 5-year survival rates for early-stage breast cancer exceed 90%.
Purpose of the Study:
- To identify significant risk factors for breast recurrence after BCT.
- To evaluate the impact of surgical margins and radiation therapy on treatment outcomes.
Main Methods:
- A multicenter case-control analysis was performed.
- Data on patient treatments and outcomes were retrospectively analyzed.
Main Results:
- Positive surgical margin was identified as a significant risk factor for breast recurrence.
- Absence of radiation therapy was also a significant risk factor for recurrence.
- The annual recurrence rate in the breast is reported as 1-2%.
Conclusions:
- Positive surgical margins and lack of radiation therapy are critical factors influencing breast recurrence after BCT.
- Adherence to guidelines regarding surgical margins and radiation is crucial for improving outcomes in breast cancer patients treated with BCT.
- Continued advancements in research and diagnostics contribute to better treatment results for breast cancer.