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[Invasive candidiasis in critically ill patients].

P Eggimann1, D Pittet

  • 1Clinique de médecine 2, Hôpitaux Universitaires de Genève. philippe.eggimann@hcuge.ch

Schweizerische Medizinische Wochenschrift
|November 25, 2000
PubMed
Summary

Invasive candidiasis, a serious hospital infection, requires early treatment and targeted prophylaxis. Careful patient selection for antifungal prophylaxis is crucial to prevent drug resistance and pathogen shifts.

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Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Mycology

Context:

  • Invasive candidiasis presents a significant challenge in healthcare settings, particularly in critical care units.
  • It is a leading cause of nosocomial infections, with high mortality rates comparable to septic shock.
  • Diagnosis remains difficult, necessitating advancements in management strategies.

Purpose:

  • To review the epidemiology, pathophysiology, and current management of invasive candidiasis.
  • To highlight the importance of early empirical or preemptive treatment strategies.
  • To emphasize the role of risk factor identification in effective antifungal prophylaxis.

Summary:

  • Invasive candidiasis occurs rarely in the general population but frequently in hospitalized patients, especially in critical care.
  • Advances in understanding pathophysiology and the availability of less toxic triazoles support early treatment approaches.
  • Effective prophylaxis relies on identifying high-risk patients to prevent resistance and shifts to non-albicans strains.

Impact:

  • Improved understanding can lead to earlier diagnosis and more effective treatment of invasive candidiasis.
  • Optimized prophylaxis strategies can reduce the incidence of this severe infection.
  • Careful use of antifungals is essential to mitigate the development of drug-resistant fungal pathogens.

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