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Updated: Aug 15, 2026

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
Swallowing and prevention of complications
1Department of Geriatric Medicine, University of Manchester, UK.
Abstract:
Dysphagia occurs in up to half of patients following a stroke. In most, it is transient with only about 1 in 10 of patients having any swallowing problems at 6 months. Persistent dysphagia may be due to lack of bilateral cerebral hemisphere representation of the oral and pharyngeal musculature involved in swallowing. Thus, the unaffected hemisphere is unable to take over the function of the damaged side. Beside assessment is not a good predictor of aspiration on videofluoroscopy, but measurement of oxygen saturation may improve this. Nevertheless, clinical detection of dysphagia may be the more powerful predictor of an increased mortality and morbidity, including pneumonia, water depletion and poor nutrition. Dysphagia is also closely related to poor nutrition following stroke, but we do not know whether feeding support will improve outcome. Major trials are on-going.
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